General Summary:

The Formulation Development team seeks a dedicated scientist to join a diligent team working to discover, develop, and commercialize therapies for patients with serious diseases. The incumbent will join our innovative preclinical formulation group to play a hands-on role in selecting drug candidates for clinical evaluation.

The ideal candidate has a fundamental understanding of chemistry and physics and has direct experience in a research laboratory (industry experience preferred). The candidate must comfortably take initiative, be curious, and show resilience in solving complex problems.

Key Duties and Responsibilities:

• Execute laboratory experiments and interpret analytical data to meet established project timelines
• Independently develop preclinical formulations of small molecule drug candidates to be dosed by various routes of administration for pharmacology, PK, and toxicology studies
• Evaluate the physicochemical/solid-state properties of lead candidates to aid in the advancement to the clinic (e.g., solubility and stability in bio-relevant media, thermal analysis, etc)
• Conduct preliminary form and salt screens of lead candidates
• Author formulation preparation instructions to transfer processes to CROs
• Maintain accurate and complete laboratory notebook in real time
• Comply with all relevant ethical, safety, and training procedures

Knowledge and Skills:

• A degree in chemistry, pharmaceutical chemistry, biochemistry, chemical engineering (or closely related major) with coursework in at least the following branches: physical, analytical, organic, and biochemistry
• Research experience conducting experiments in the laboratory (industry experience preferred)
• Knowledge of solid-state analytical techniques including XRPD, DSC, TGA, DVS
• HPLC experience
• Direct experience with evaluating the physicochemical properties of small molecule compounds
• Solid understanding of amorphous solid dispersions
• Strong technical writing and excellent verbal communication skills

Education and Experience:

• Masters Degree (or equivalent degree) in a related physical sciences and 2+ years of relevant employment experience, or
• Bachelor’s Degree (or equivalent degree) in a related physical science sciences and 5+ years of relevant employment experience

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com